Work is set to take place on Longdales Road in two spells over a total of 16 days.
Patching works will be carried out along the west end of the road, near the entrance/exit of Bishop Grosseteste University, on Thursday and Friday, March 21-22.
As part of this, two-way temporary traffic lights will be in place on Longdales Road from 7pm to 6am over both evenings.
The contractor will then return on Tuesday, April 23 for two weeks, to reconstruct the full extent of Longdales Road.
Officials say this work will take place during the day under a 24/7 eastbound road closure for the first 12 days of that fortnight.
The last two days of work will be carried out under a full daytime road closure, from 8am to 6pm, so that the final surface course can be laid and road markings reinstated.
The diversion route for the one-way closure and two-day closure will be via Nettleham Road / A15 Lincoln Bypass / Riseholme Road, and vice versa.
In addition, Ravendale Road Drive will be closed during the full road closure to allow a safe working space. A local diversion will be in place.
Richard Davies, executive member for highways, said: "We've decided to carry out an initial two evenings of patching work so that the worst sections of Longdales Road are made safe in time for the Lincoln 10k on Sunday 7 April.
"We'd have liked to have had the whole road fully rebuilt in time for this year's race, but, due to a combination of contractor availability and other works happening on the network, it just wasn't possible.
"Instead, we'll be returning to Longdales Road during mid/late April to reconstruct the whole of it since the road's surfacing is nearing the end of its serviceable life.
"I want to thank everyone for bearing with us during these works and want to reassure residents and road users that we'll be doing everything we can to minimise disruption during both sets of works."
For up-to-date information about this and other roadworks, visit www.lincolnshire.gov.uk/roadworks
