Manchester's Nightingale hospital will close this month once its last Covid patient has been discharged.
The NHS Nightingale North West, built at Manchester Central in response to the coronavirus outbreak, will close to new admissions and be put on standby.
All acute hospitals in the North West are said to have enough capacity to admit coronavirus patients.
The extra bed capacity at the Nightingale North West is no longer needed, say NHS bosses.
However, the hospital could be used again should there be another peak or second wave in cases.
In a note sent out to staff, bosses warn that the number of COVID patients could rise as social distancing restrictions are eased.
The NHS is also considering a new role for the Nightingale facility as hospitals resume routine appointments and elective treatment.
A statement sent out to staff by NHS England and NHS Improvement said: "The NHS Nightingale Hospital North West opened in Manchester to ensure extra capacity was available, if it was needed, to the region’s acute hospitals.
"We are now in the second phase of this pandemic and the acute hospitals in the North West have demonstrated that they are now able to admit all the COVID-19 patients who currently require treatment, and this will reduce the number of referrals to the Nightingale.
"As a result, after the last patient leaves, the hospital will be placed on standby, ready to resume operations as and when needed in the weeks and potentially months to come.
"This does not mean the Nightingale’s role in the North West’s response to the virus is over. We must be ready for the possibility that the number of COVID-19 cases rise again as social distancing rules are eased.
"Work is also underway to consider how the Nightingale’s role may further adapt as the NHS seeks to resume activity that had to be paused in the first phase of our response to the pandemic.
"The hospital has been a fantastic achievement and thank you to all the organisations that supported this ambitious project, and to everyone who has worked with great energy and commitment in challenging circumstances to help save lives."
It's understood that the majority of patients treated at the Nightingale were over the age of 75.
In total, three coronavirus patients have died at the temporary facility since it opened in April.
London's flagship field hospital, built at London's ExCel centre for critically ill Covid patients, was put on standby in May.
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